Shere Khan is first seen attending the jungle meeting called by Hathi. He then contemplates on who he is going to eat, with his sidekick, Tabaqui, the hyena, telling jokes about it, much to the tiger's annoyance. He then decides to hunt man, claiming to have a craving for "Indian food". He and Tabaqui then ambush some humans visiting the river, but when he is shot at by hunters, he flees and is assumed dead. Years later, he reveals himself alive to the wolf pack and demands that Mowgli is given to him, but Akela refuses, and Shere Khan swears revenge. He is later seen conspiring with the wolf pack bullies about separating Mowgli from the pack, which succeeds. He and Tabaqui then conspire with the chimps about separating Mowgli from Bagheera and Baloo.
The chimps then inform Shere Khan that they've succeeded in capturing Mowgli, and he and Tabaqui head there. En route, Shere Khan runs into Raksha and kills her. By the time Shere Khan arrives in Monkey Town, Mowgli had escaped with help from Baloo and Bagheera. The enraged tiger then attacks the chimps. Whether or not he killed them is unknown.
Later, Mowgli lures Shere Khan into a trap by having him chase him to the river. Shere Khan at first scoffs at the notion that Mowgli can defeat him, but Mowgli forms a circle of fire around the tiger, frightening him and causing Tabaqui to desert him. Mowgli then makes Shere Khan to swear that he will leave the jungle and never return, threatening him should he break his word. The frightened tiger agrees, and flees the jungle forever.